Acute Isoniazid Neurotoxicity

Pyridoxine in acute isoniazid overdose.

Isoniazid is the mainstay of antitubercular therapy and is included in nearly every drug regime. Cases of intentional and accidental overdose have been reported(l,2) though with less than expected frequency considering the drug's extensive use. The principal manifestations of isoniazid overdose include recurrent seizures, metabolic acidosis and coma(3,4). We report two cases of isoniazid overdo...

Ropivacaine induced acute neurotoxicity after epidural injection.

Ropivacaine is an amide-type long acting local anaesthetic. According to experimental and human data, its toxicity for Central Nervous System (CNS) and Cardiovascular System (CVS) is considered lower than toxicity related to bupivacaine, the now-a-days accepted golden standard for long acting local anaesthetics. Nevertheless, reports about this kind of accidents are fairly numerous. Aim of this...

Starfruit neurotoxicity mimicking an acute brainstem stroke.

Protective Role of Oleuropein against Acute Deltamethrin- Induced Neurotoxicity in Rat Brain

Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, leading to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. The purpose of this study was to determine the anti-apoptotic effect of OE pretreatment in the neuronal cells of cerebral cortex. Methods: Rats were randomly divided into four groups each containin...

Acute pellagra in a child under treatment with isoniazid.

Toxic manifestations during isoniazid therapy are encountered in less than 5% of cases treated, and we have been able to trace little mention of them in children in the literature. The drug is now widely used in the treatment of tuberculosis and is universally prescribed as an adjuvant to streptomycin in tuberculous meningitis. The following case report concerns a child who developed pellagra l...